winstonw wrote:chriscole wrote:If you can manage 39 bananas in one sitting, go for it.... then drop by my hospital so I can check your potassium level, coz I'd be quite interested
Chris
I'd like to know your hospital's name....because if it hasn't been capable of informing you of the lethal dose of bananas for people with healthy renal function, I want to avoid it.
In someone with normal renal function who's not taking any medications which lower GFR, affect potassium-handling in the nephron, or alter the sensitivity of cardiac myocytes to small changes in serum [K+], it should be
almost impossible to ingest enough bananas to knock yourself off via hyperkalaemia.
Thus, knowing the LD50 for bananas isn't really a high priority on most emergency physician's "things I need to know" list.
Interestingly, a chick with a serious banana fetish did the hard yards (inadvertently) for medical science, and showed that 20 bananas a day for prolonged periods does indeed raise one's serum potassium level, but not that much. Mind you, when it was measured, her body was probably pretty well-adapted to the consistent huge K+ intake. Acutely, you might expect a slightly different picture, though renal handling of K+ is rapidly adaptive.
http://www.ncbi.nlm.nih.gov/pubmed/17194559" onclick="window.open(this.href);return false;
And an older person with renal dysfunction and a combination of nephrotoxic medications who died with profound hyperkalaemia thought to be secondary to banana obsession.
http://www.ncbi.nlm.nih.gov/pubmed/17194559" onclick="window.open(this.href);return false;
Anecdotally, I've seen a couple of patients with significant (i.e. causing ECG changes +/- dysrhythmias) hyperkalaemia secondary to scoffing high-K+ foods, but they were in the setting of older folk with mild renal impairment to start with (and it was grapes, and apricots, not bananas).